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US 7,605,164 B2Granted
Compositions and methods for treating heart failure
AssigneeCytokinetics, Inc.
InventorsFady Malik, Adam Lewis Tomasi, Bainian Feng, Erica Anne Kraynack, Kathleen A. Elias, Pu-Ping Lu, Whitney Walter Smith, Xiangping Qian, David J. Morgans, Jr.
Life of this patent
Estimating the term…
Abstract
Certain substituted benzamide derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
Claims15
A method of potentiating cardiac myosin, which method comprises administering to a mammal in need thereof an amount of a compound represented by Formula I effective to potentiate cardiac myosin
- wherein:
- R1 is alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl;
- R2 is acetyl, acetylamino, acetylene, alkoxycarbonyl, carboxamido, cyano, halo, heteroaryl, hydrogen, nitro or trifluoromethyl;
- and
- R3 is aryl, substituted aryl, heteroaryl or substituted heteroaryl;
- or a single stereoisomer, or mixture of stereoisomers, or a pharmaceutically acceptable salt thereof,
- wherein “substituted” alkyl, aryl, and heteroaryl refer respectively to alkyl, aryl, and heteroaryl wherein one to three hydrogen atoms are replaced by a substituent independently selected from alkyl, fluoroalkyl, alkoxy, cyano, halogen, hydroxy, and nitro.
4 more elements
Dependencies are inferred from the claim text.