Modulation of the phospholipase A2 pathway as a therapeutic
AssigneeUniversity of South Florida
InventorsDaniel Paris, Terrence C. Town, Michael J. Mullan
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Abstract
There is provided a method of modifying vasoactivity by regulating a soluble Aβ pro-inflammatory pathway. Also provided is a method of modifying inflammatory reactions in microglia and neurons by regulating a soluble Aβ pro-inflammatory pathway. A method of treating patients with vascular disease by modifying an intracellular soluble Aβ pro-inflammatory pathway is also provided. A pharmaceutical composition consisting essentially of an effective amount of a soluble Aβ pro-inflammatory pathway regulator in a pharmaceutically effective carrier is also provided.
Claims10
A method of modifying beta-amyloid-induced vasoactivity in individuals with Alzheimer's Disease or other vascular-related diseases or disorders, in which said vascular-related diseases or disorders are selected from the group consisting of cerebral amyloid angiopathy, vascular amyloidosis, hypertension and vasospasm associated with severe post-traumatic head injury, comprising antagonizing the secretory phospholipase A2/arachidonic acid/5-lipoxygenase/cyclo-oxygenase-2 pro-inflammatory pathway by administering a pharmaceutically effective amount of oleyloxyethylphosphocholine to the individual in an amount ranging from between 0.1 μg to 10 mg/kg body weight/day.
A method of treating cerebral amyloid angiopathy, vascular amyloidosis, hypertension or vasospasm associated with severe post-traumatic head injury in an individual, the method comprising administering a pharmaceutically effective amount of oleyloxyethylphosphocholine to the individual.
Dependencies are inferred from the claim text.