Acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same

A nucleoside phosphonate derivative represented by the following formula (1):

• in which
• represents single bond or double bond,
• R1, R2, R3, R7 and R8 independently of one another represent hydrogen, halogen, hydroxy, amino, C1-C7-alkyl, C2-C6-alkenyl, C1-C5-alkylamino, C1-C5-aminoalkyl, or C1-C5-alkoxy, R4 and R5 independently of one another represent hydrogen, or represent C1-C4-alkyl optionally substituted by one or more substituents selected from the group consisting of halogen, C1-C4-alkoxy, phenoxy, C7-C10-phenylalkoxy and C2-C5-acyloxy, wherein C2-C5-acyloxy is RC(O)O—, and R is C2-C5 alkyl, or represent C1-C7-acyl, wherein C1-C7-acyl is RC(O)—, and R is C1-C7 alkyl, C6-C12-aryl or optionally substituted carbamoyl, or represent —(CH2)m-OC(═O)—R6 wherein m denotes an integer of 1 to 12 and R6 represents C1-C12-alkyl, C2-C7-alkenyl, C1-C5-alkoxy, C1-C7-alkylamino, di(C1-C7-alkyl)amino, C3-C6-cycloalkyl, or 3 to 6-membered heterocycle having 1 or 2 hetero atoms selected from a group consisting of nitrogen and oxygen,
• Y represents —O—, —S—, —CH(Z)-, ═C(Z)-, —N(Z)-, ═N—, or —SiH(Z)-, wherein Z represents hydrogen, hydroxy or halogen, or represents C1-C7-alkyl, C1-C5-alkoxy, allyl, hydroxy-C1-C7-alkyl, C1-C7-aminoalkyl or phenyl,
• Q represents a group having the following formula:
• wherein
• X1, and X2 independently of one another represent hydrogen, amino, hydroxy or halogen, or represent C1-C7-alkyl, C1-C5-alkoxy, allyl, hydroxy-C1-C7-alkyl, phenyl or phenoxy each of which is optionally substituted by nitro or C1-C5-alkoxy, or represent C6-C10-arylthio which is optionally substituted by nitro, amino, C1-C6-alkyl or C1-C4-alkoxy, or represent C6-C12-arylamino, C1-C7-alkylamino, di(C1-C7-alkyl)amino, C3-C6-cycloalkylamino or a structure of
• wherein n denotes an integer of 1 or 2 and Y1 represents O, CH2 or N—R (R represents C1-C7-alkyl or C6-C12-aryl), wherein at least one of X1 and X2 must be either amino or hydroxy, pharmaceutically acceptable salt, or stereoisomer thereof.