Nucleic acid compositions for stimulating immune responses
AssigneeColey Pharmaceutical Group, Inc.
InventorArthur M. Krieg
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Abstract
The invention provides an immunostimulatory nucleic acid comprising CpG motifs, and methods of use thereof in stimulating immunity.
Claims50
A composition comprising
- an immunostimulatory nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:1, wherein the immunostimulatory nucleic acid has a nucleotide backbone comprising at least one phosphorothioate modification, and wherein the immunostimulatory nucleic acid comprises a CpG motif which is unmethylated.
A method for stimulating an immune response in a subject in need thereof comprising administering to a subject a composition comprising an immunostimulatory nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:1, in an amount effective to stimulate an immune response, wherein in the immunostimulatory nucleic acid comprises a CpG motif which is unmethylated.
A method for inducing an innate immune response, comprising administering to the subject a composition comprising an immunostimulatory nucleic acid comprising the nucleotide sequence of SEQ ID NO:1, in an amount effective for activating an innate immune response, wherein the immunostimulatory nucleic acid comprises a CpG motif which is unmethylated.
A composition comprising an immunostimulatory nucleic acid comprising the nucleotide sequence of SEQ ID NO:1, wherein the immunostimulatory nucleic acid is 21-100 nucleotides in length, and wherein the immunostimulatory nucleic acid comprises a CpG motif which is unmethylated.
A composition comprising an immunostimulatory nucleic acid comprising the nucleotide sequence of SEQ ID NO:1 and an antigen, wherein the immunostimulatory nucleic acid comprises a CpG motif which is unmethylated.
A composition comprising an immunostimulatory nucleic acid comprising the nucleotide sequence of SEQ ID NO:1, wherein the immunostimulatory nucleic acid is single stranded and wherein the immunostimulatory nucleic acid comprises a CpG motif which is unmethylated.
A composition comprising an immunostimulatory nucleic acid consisting of the nucleotide sequence of SEQ ID NO:1, wherein the immunostimulatory nucleic acid comprises a CpG motif which is unmethylated.
Dependencies are inferred from the claim text.