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US 7,605,129 B2Granted
Splice variant of human placental growth hormone
OwnerRichard Joseph Fagan, Christopher Benjamin Phelps +3inventors
InventorsRichard Joseph Fagan, Christopher Benjamin Phelps, Tania Maria Rodrigues, Christine Power, Mariastella De Tiani
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Abstract
This invention relates to a protein, termed INSP105, herein identified as a splice variant of human placental growth hormone and to the use of this protein and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.
Claims26
An isolated polypeptide selected from the group consisting of:
- a) a polypeptide comprising SEQ ID NO:8 or SEQ ID NO:10;
- b) a polypeptide comprising a fragment of SEQ ID NO:8 or SEQ ID NO:10, wherein said fragment functions as a growth hormone;
- c) a polypeptide consisting of SEQ ID NO:8 or SEQ ID NO:10;
- d) a polypeptide that has greater than 96% identity to SEQ ID NO:
- 8 or SEQ ID NO:
- 10 and wherein said wherein said polypeptide functions as a growth hormone;
- and
- e) a polypeptide comprising a fragment of the polypeptide according to d) and wherein said fragment functions as a growth hormone.
5 more elements
A composition comprising a pharmaceutically acceptable carrier and a polypeptide selected from the group consisting of:
- a) a polypeptide comprising SEQ ID NO:8 or SEQ ID NO:10;
- b) a polypeptide comprising a fragment of SEQ ID NO:8 or SEQ ID NO:10, wherein said fragment functions as a growth hormone;
- c) a polypeptide consisting of SEQ ID NO:8 or SEQ ID NO:10;
- d) a polypeptide that has greater than 96% identity to SEQ ID NO:
- 8 or SEQ ID NO:
- 10 and wherein said polypeptide functions as a growth hormone;
- and
- e) a polypeptide comprising a fragment of the polypeptide according to d) and wherein said fragment functions as a growth hormone.
5 more elements
Dependencies are inferred from the claim text.