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US 7,605,005 B2Granted
Method of screening for agents that modulate Tysnd1 level or activity in a cell.
AssigneesRiken, Saitama Medical University
InventorsIgor Kurochkin, Christian Schoenbach, Yasushi Okazaki
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Abstract
The invention relates to a pharmaceutical composition for treating or diagnosing a disorder associated with production of peroxisome in a cell, comprising a polypeptide which has cysteine protease activity and directly processes peroxisomal enzymes targeted by PTS1 or PTS2 signals. Preferably, the polypeptide is encoded by Tysnd1.
Claims6
A method for screening for an agent that can modulate Tysnd1 levels in a cell, comprising steps of:
- contacting an animal cell with a candidate substance;
- estimating an amount of Tysnd1 in the cell;
- identifying the candidate substance as the agent if the amount of Tysnd1 is modulated with respect to a control.
A method for screening for an agent that can modulate Tysnd1 activity in a cell, comprising the steps of:
- contacting an animal cell with a candidate substance;
- measuring Tysnd1 activity in said cell;
- and identifying the candidate substance as the agent if the activity of Tysnd1 in the cell is modulated with respect to a control.
Dependencies are inferred from the claim text.