Back to results
US 7,605,003 B2Granted
Use of biomarkers for detecting ovarian cancer
AssigneesThe Johns Hopkins University, Vermillion, Inc.
InventorsDaniel W. Chan, Zhen Zhang, Eric Fung, Xiao-Ying Meng
Life of this patent
Estimating the term…
Abstract
The present invention relates to a method of qualifying ovarian cancer status in a subject comprising: (a) measuring at least one biomarker in a sample from the subject and (b) correlating the measurement with ovarian cancer status. The invention further relates to kits for qualifying ovarian cancer status in a subject.
Claims35
A method of determining if a subject has ovarian cancer comprising:
- (a) measuring in a sample from the subject the amount of apolipoprotein A1 (ApoA1) and of a cleavage fragment of inter-α-trypsin inhibitor heavy chain H4 (IAIH4 fragment), wherein the IAIH4 fragment consists of the amino acid sequence of SEQ ID NO:
- 1 and
- (b) comparing the amounts measured in step (a) with the amount of ApoA1 and of IAIH4 fragment measured in a sample from a control, wherein a decrease in the amount of ApoA1 in the sample as compared to the control sample, and an increase in the amount of IAIH4 fragment in the sample as compared to the control sample indicates that the subject has ovarian cancer.
A method of qualifying ovarian cancer status in a subject comprising:
- (a) measuring in a sample from the subject the amount of ApoA1 and of IAIH4 fragment, wherein the IAIH4 fragment consists of the amino acid sequence of SEQ ID NO:
- 1, and
- (b) comparing the amounts measured in step (a) with the amount of ApoA1 and of IAIH4 fragment measured in a sample from a control, wherein ovarian cancer status is the presence or absence of ovarian cancer, wherein a decrease in the amount of ApoA1 in the sample as compared to the control sample, and an increase in the amount of IAIH4 fragment in the sample as compared to the control sample is indicative of the presence of ovarian cancer in the subject.
Dependencies are inferred from the claim text.