Bioreactor for growing cell or tissue cultures

A method for growing cell or tissue cultures in vitro comprising the steps of:

• (a) providing a chamber having a cell or tissue culture within a culture medium;
• (b) rotating the chamber about a first axis at a first speed;
• (c) rotating the chamber about a second axis at a second speed, the second axis being disposed at an angle relative to the first axis, and wherein the magnitude of the first speed and the second speed are independently variable of each other;
• and
• (d) adjusting the angle between the first axis and the second axis.

A bioreactor comprising:

• a substantially spherical or substantially elliptical shaped chamber capable of containing cell or tissue culture within a culture medium;
• a chamber support to support the chamber and comprising rollers to allow the chamber to rotate about at least a first axis and a second axis, the second axis being disposed at an angle relative to the first axis;
• a chamber drive capable of rotating the chamber at a first speed about the first axis and a second speed about the second axis, wherein in use, the magnitude of the first speed and the second speed are independently variable of each other;
• and
• an adjustment mechanism capable of adjusting the angle between the second axis and first axis.