Inhibition of biofilm formation
AssigneeSequoia Sciences, Inc.
InventorGary R. Eldridge
Life of this patent
Estimating the term…
Abstract
The present invention relates to compositions and methods for reducing or inhibiting biofilm comprising modulating expression of a cysB gene in a cell. The invention also provides methods for modulating the expression of a cysB, cysD, cysI, cysJ, cysK, and ybiK. The invention further provides methods for identifying gene(s) involved in biofilm formation and for identifying biofilm inhibitors.
Claims15
A method for reducing or inhibiting a biofilm comprising modulating expression of a cysB gene present in a Gram-negative bacteria cell capable of biofilm formation, thereby to reduce or inhibit the biofilm formation.
A method for modulating the expression of cysB, comprising contacting a Gram-negative bacteria cell capable of biofilm formation with a composition comprising a compound selected from the group consisting of ursolic acid or asiatic acid, or a pharmaceutically acceptable salt of such compound, a hydrate of such compound, a solvate of such compound, a N-oxide of such compound, or a combination thereof.
Dependencies are inferred from the claim text.