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US 7,604,951 B2Granted
Method for identifying compounds that modulate RXR associated processes with IgE production
AssigneeRigel Pharmaceuticals, Inc.
InventorsTodd M. Kinsella, Esteban Masuda, Mark K. Bennett, Justin E. Warner, David C. Anderson
Life of this patent
Estimating the term…
Abstract
The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a retinoid X receptor as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.
Claims11
A method of identifying a compound that modulates interleukin-4 (IL-4) receptor-mediated immunoglobulin-E (IgE) production, comprising:
- a) assaying a compound for modulation of an retinoid-X-receptor (RXR) protein;
- and
- b) assaying said compound for modulation of IL-4 induced IgE production.
Dependencies are inferred from the claim text.