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US 7,604,948 B2Granted
Biomarkers for diagnosing an autism spectrum disorder
AssigneeThe Regents of the University of California
InventorsDavid G. Amaral, Blythe A. Corbett
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Abstract
The present invention provides methods of identifying biomarkers indicative of the presence of a neurodevelopmental disorder, including an autism spectrum disorder, in an individual, using cytometry and mass spectrometry. The invention further provides methods of using the identified biomarkers to diagnose the presence of a neurodevelopmental disorder, including an autism spectrum disorder.
Claims15
A method for diagnosing an autism spectrum disorder in an individual, said method comprising:
- a) determining the level of complement factor H-related protein (FHR1) in a blood or serum sample from a first individual exhibiting symptoms of an autism spectrum disorder;
- and
- b) comparing the level of the FHR1 determined in step a) with the level of the FHR1 in a control sample from a second individual or a population of individuals who do not have an autism spectrum disorder;
- wherein levels of increased complement factor H-related protein (FHR1) in the sample from the first individual in comparison to the control sample from the second individual or population of individuals is indicative of an autism spectrum disorder.
1 more element
Dependencies are inferred from the claim text.