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AssigneeDainippon Sumitomo Pharma Co., Ltd.
InventorsNorihito Shimono, Masaaki Mori, Yutaka Higashi
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A colonic delivery solid preparation containing chitosan powder, which can control the dissolution of a medicament therefrom in the large intestine and release the medicament contained therein specifically in the large intestine, obtained by successively coating a medicament-containing solid material with (1) a water-insoluble polymer having a chitosan powder dispersed therein and (2) an enteric polymer; and a solid preparation containing chitosan powder, which can partly release a medicament in the stomach and, after passing through the small intestine, disintegrate at an accelerated rate in the large intestine and release a medicament in the large intestine, obtained by coating a medicament-containing solid material with a water-insoluble polymer having a chitosan powder dispersed therein.
A sustained release preparation comprising a medicament-containing solid material and a water-insoluble coating film, wherein said medicament-containing solid material consists of a medicament and a pharmaceutical excipient, and said water-insoluble coating film consists essentially of a water-insoluble polymer and a chitosan powder dispersed in said polymer, wherein said polymer is selected from the group consisting of ethyl cellulose, ethyl acrylate-methyl methacrylate-trimethylammoniumethyl methacrylate chloride copolymer, and methyl methacrylate-ethyl acrylate copolymer, said chitosan powder having a mean particle size diameter in the range of about 0.5 μm to about 400 μm, and the weight ratio of said polymer and said chitosan powder is from 4:1 to 1:4.
Dependencies are inferred from the claim text.