Polymers of fluorinated monomers and hydrocarbon monomers
AssigneeAdvanced Cardiovascular Systems, Inc.
InventorStephen D. Pacetti
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Abstract
A polymer of fluorinated monomers and hydrocarbon monomers is provided. It is also provided a polymer blend that contains a polymer formed of fluorinated monomers and hydrocarbon monomers and another biocompatible polymer. The polymer or polymer blend described herein and optionally a bioactive agent can form an implantable device such as a stent or a coating on an implantable device such as a drug-delivery stent, which can be used for treating or preventing a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.
Claims10
An implantable device having a biocompatible coating thereon, wherein the biocompatible coating comprises a random biocompatible polymer comprising fluorinated monomers and hydrocarbon monomers,
- wherein the hydrocarbon monomers are CHR═CH2 in which R is selected from the group consisting of phenyl, substituted phenyl, cyclic alkyl, heterocyclic alkyl, and heteroaryl, or CR2═CH2 in which R is selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, short chain alkyl groups, phenyl, substituted phenyl, cyclic alkyl, heterocyclic alkyl, and heteroaryl,
- wherein the fluorinated monomers form about 25.01 mole % to about 99.99 mole % repeating units of the polymer, and
- wherein the hydrocarbon monomers form about 74.99 mole % to about 0.01 mole % repeating units of the polymer.
An implantable device having a biocompatible coating thereon, wherein the biocompatible coating comprises a random biocompatible polymer comprising fluorinated monomers and hydrocarbon monomers,
- wherein the hydrocarbon monomers are CHR═CH2 in which R is selected from the group consisting of phenyl, substituted phenyl, cyclic alkyl, heterocyclic alkyl, and heteroaryl or CR2═CH2 in which R is selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, short chain alkyl groups, phenyl, substituted phenyl, cyclic alkyl, heterocyclic alkyl, and heteroaryl,
- wherein the fluorinated monomers form about 50.01 mole % to about 94.99 mole % units of the polymer, and
- wherein the hydrocarbon monomers form about 49.99 mole % to about 5.01 mole % repeating units of the polymer.
A stent formed of a material comprising a random biocompatible polymer comprising fluorinated monomers and hydrocarbon monomers,
- wherein the hydrocarbon monomers are CHR═CH2 in which R is selected from the group consisting of phenyl, substituted phenyl, cyclic alkyl, heterocyclic alkyl, and heteroaryl or CR2═CH2 in which R is selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, short chain alkyl groups, phenyl, substituted phenyl, cyclic alkyl, heterocyclic alkyl, and heteroaryl,
- wherein the fluorinated monomers form about 25.01 mole % to about 99.99 mole % repeating units of the polymer, and
- wherein the hydrocarbon monomers form about 74.99 mole % to about 0.01 mole % repeating units of the polymer.
A stent formed of a material comprising a random biocompatible polymer comprising fluorinated monomers and hydrocarbon monomers,
- wherein the hydrocarbon monomers are CHR═CH2 in which R is selected from the group consisting of phenyl, substituted phenyl, cyclic alkyl, heterocyclic alkyl, and heteroaryl CR2═CH2 in which R is selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, short chain alkyl groups, phenyl, substituted phenyl, cyclic alkyl, heterocyclic alkyl, and heteroaryl,
- wherein the fluorinated monomers form about 50.01 mole % to about 94.99 mole % repeating units of the polymer,
- wherein the hydrocarbon monomers form about 49.99 mole % to about 5.01 mole % repeating units of the polymer
Dependencies are inferred from the claim text.