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US 7,604,804 B2Granted
Enhancing anti-HIV efficiency through multivalent inhibitors targeting oligomeric gp120
AssigneeUniversity of Maryland Biotechnology Institute
InventorsLai-Xi Wang, Hengguang Li
Life of this patent
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Abstract
The present invention relates to multivalent HIV inhibitors that bind to multiple sites on a trimeric gp120 complex thereby blocking the CD4 binding site on the trimeric gp120 complex and inhibiting the attachment and entry of HIV through gp120-CD4 interactions.
Claims21
A bivalent complex comprising:
- two gp120 binding molecules that target the CD4 binding pocket on a trimeric HIV gp120 complex;
- and
- a flexible bivalent spacer/linker attached to the gp120 binding molecules and positioned therebetween, wherein the flexible bivalent spacer/linker is of sufficient length to provide for binding of the gp120 binding molecules to the CD4 binding sites on the trimeric HIV gp120 complex.
Dependencies are inferred from the claim text.