Method of obtaining cellular immune responses from proteins
AssigneeNovartis Vaccines and Diagnostics, Inc.
InventorsDerek O'Hagan, Manmohan Singh
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Abstract
A method for producing a cellular immune response in a vertebrate subject comprising administering to the vertebrate subject a vaccine composition comprising a protein particle antigen and a pharmaceutically acceptable excipient is disclosed.
Claims29
A method for producing a cytotoxic-T lymphocyte (CTL) response in a vertebrate subject comprising administering to said vertebrate subject an immunologically effective amount of an immunogenic composition that comprises a precipitated protein particle and a pharmaceutically acceptable excipient, wherein said precipitated protein particle is not formed from protein that spontaneously forms into virus-like particles, wherein said precipitated protein particle is not provided on or within a carrier particle, wherein said protein particle is formed from a protein that is not a lipoprotein, and wherein said particle is generally spherical in shape.
A method for producing a cellular immune response in a vertebrate subject comprising administering to said vertebrate subject an immunologically effective amount of an immunogenic composition that comprises a precipitated protein particle and a pharmaceutically acceptable excipient, wherein said precipitated protein particle is not formed from protein that spontaneously forms into virus-like particles, wherein said precipitated protein particle is not provided on or within a carrier particle, wherein said precipitated protein particle is formed from a protein that is not a lipoprotein, and wherein said particle is generally spherical in shape.
Dependencies are inferred from the claim text.