Nanoparticles for protein drug delivery
AssigneesGP Medical, Inc., National Tsing Hua University
InventorsHsing-Wen Sung, Hsiang-Fa Liang, Hosheng Tu
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Abstract
The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular protein drug and bioactive agent delivery.
Claims20
A bioactive agent delivery system for enhancing the epithelial permeation of at least one bioactive agent, comprising nanoparticles or collapsed nanoparticles, said nanoparticles or said collapsed nanoparticles comprising an outer portion that is dominated by positively charged chitosan, an inner portion that contains negatively charged substrate, wherein said substrate is PGA, wherein said negatively charged substrate is at least partially reacted with a portion of said positively charged chitosan in the inner portion, and said at least one bioactive agent loaded within said nanoparticles or said collapsed nanoparticles.
Dependencies are inferred from the claim text.