Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
AssigneeImmunoGen, Inc.
InventorRavi V. J. Chari
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Abstract
The present invention is based on the discovery that the administration of at least one immunoconjugate and at least one chemotherapeutic agent provides an unexpectedly superior treatment for cancer. The present invention is directed to compositions comprising at least one immunoconjugate and at least one chemotherapeutic agent and to methods of treating cancer using at least one immunoconjugate and at least one chemotherapeutic agent. The present invention also provides methods of modulating the growth of selected cell populations, such as cancer cells, by administering a therapeutically effective amount of at least one chemotherapeutic agent and at least one immunoconjugate.
Claims17
A method of treating cancer in a patient in need thereof comprising administering to the patient a therapeutically effective amount of a synergistic combination of at least one chemotherapeutic agent and at least one immunoconjugate, wherein the immunoconjugate comprises at least one cell binding agent and at least one maytansinoid compound, and wherein the chemotherapeutic agent is a taxane compound, an epothilone compound, a platinum compound, an epipodophyllotoxin compound, a camptothecin compound, or a combination of two or more thereof.
A method of modulating the growth of a selected cell population comprising administering to the selected cell population a therapeutically effective amount of a synergistic combination of at least one chemotherapeutic agent and at least one immunoconjugate, wherein the immunoconjugate comprises at least one cell binding agent and at least one maytansinoid compound, and wherein the chemotherapeutic agent is a taxane compound, an epothilone compound, a platinum compound, an epipodophyllotoxin compound, a camptothecin compound, or a combination of two or more thereof, and wherein the selected cell population comprises cancer cells.
Dependencies are inferred from the claim text.