Apparatus and method for coding genetic information

A method for predicting probe hybridization to a DNA chip, comprising:

• receiving sample genetic information, wild-type probe genetic information, mutant-type probe genetic information, and a mutation position for each type of genetic information from a user of a DNA chip;
• aligning the sample genetic information, the wild-type probe genetic information, and the mutant-type probe genetic information at the mutation position in each type of genetic information;
• coding the aligned genetic information by creating first code strings and second code strings,
• the first code strings being created by assigning first orthogonal codes, sequentially from left to right excluding the mutation position, to bases in the aligned genetic information and adding a flag to the assigned first orthogonal codes that represents the presence or absence of a corresponding base in each type of genetic information, and
• the second code strings being created by assigning second orthogonal codes to a base located at the mutation position and adding a flag to the assigned second orthogonal codes that represents whether the base located at the mutation position of the sample genetic information is wild-type or mutant-type;
• inputting the coded aligned genetic information into a neural network trained to predict results of hybridization to the DNA chip;
• and
• outputting from the neural network the hybridization intensity ratios between wild-type probes and mutant-type probes, or the transformed values thereof, to the user of the DNA chip.