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US 7,599,055 B2Granted
Swept wavelength imaging optical interrogation system and method for using same
AssigneeCorning Incorporated
InventorsJacques Gollier, Qi Wu
Life of this patent
Estimating the term…
Abstract
A swept wavelength imaging optical interrogation system and a method for using the same to interrogate one or more biosensors are described herein. The swept wavelength imaging optical interrogation system is built upon a swept wavelength optical interrogation technology where a 2-D label free image is extracted from a series of high speed spectral images of the biosensor(s) without the need of performing mechanical scanning.
Claims23
An interrogation system comprising:
- a tunable laser that has a tuning range wherein an optical beam is emitted therefrom which has a predetermined sequence of distinct wavelengths over a predetermined time period;
- illumination optics that converts the optical beam into one or more interrogation beams which illuminate one or more biosensors;
- imaging optics that collects an image from the illuminated one or more biosensors;
- a 2-D imaging device that obtains a sequence of the collected images each of which corresponds with one of the distinct wavelengths of the optical beam emitted from said tunable laser;
- and
- a data processing device that receives the collected images and processes the collected images to:
- determine whether or not there was a biochemical interaction on each of the one or more biosensors;
- locate sensor region(s) and/or reference region(s) on each of the one or more biosensors;
- remove defect regions on each of the one or more biosensors;
- and/or
- calibrate a uniformity of surface chemistry and target molecule immobilizations on each of the one or more biosensors.
8 more elements
A method for interrogating one or more biosensors said method comprising the steps of:
- emitting an optical beam which has a predetermined sequence of distinct wavelengths over a predetermined time period;
- converting the optical beam into one or more interrogation beams which illuminates one or more biosensors;
- collecting an image from the illuminated one or more biosensors;
- obtaining a sequence of the collected images each of which corresponds with one of the distinct wavelengths of the emitted optical beam;
- and
- processing the collected images, wherein a data processing device is used to process the collected images to:
- determine whether or not there was a biochemical interaction on each of the one or more biosensors;
- locate sensor region(s) and/or reference region(s) on each of the one or more biosensors;
- remove defect regions on each of the one or more biosensors;
- and/or
- calibrate a uniformity of surface chemistry and target molecule immobilizations on each of the one or more biosensors.
8 more elements
A method for interrogating one or more biosensors, said method comprising the steps of:
- emitting an optical beam which has a predetermined sequence of distinct wavelengths over a predetermined time period;
- converting the optical beam into one or more interrogation beams which illuminate one or more biosensors;
- collecting an image from the illuminated one or more biosensors;
- obtaining a sequence of the collected images each of which corresponds with one of the distinct wavelength of the emitted optical beam;
- and
- processing the collected images to locate sensor region(s) and/or reference region(s) on each of the one or more biosensors.
3 more elements
A method for interrogating one or mere biosensors said method comprising the steps of;
- emitting an optical beam which has a predetermined sequence of distinct wavelength over a predetermined time period;
- converting the optical beam into one or more interrogation beams which illuminate one or more biosensors;
- collecting an image from the illuminated one or more biosensors;
- obtaining a sequence of the collected images each of which corresponds with one of the distinct wavelengths of the emitted optical beam;
- and
- processing the collected images to remove defect regions on each of the one or more biosensors.
3 more elements
A method for interrogating one or more biosensors, said method comprising the steps of:
- emitting an optical bean which has a predetermined sequence of distinct wavelengths over a predetermined time period;
- converting the optical be in into one or more interrogation beams which illuminate one or more biosensors;
- collecting an image from the illuminated one or more biosensors;
- obtaining a sequence of the collected images each of which corresponds with one of the distinct wavelengths of the emitted optical beam;
- and
- processing the collected images to calibrate a uniformity of surface chemistry and target molecule immobilizations on each of the one or more biosensors.
3 more elements
Dependencies are inferred from the claim text.