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US 7,598,419 B2Granted
Compounds for modulating cell proliferation
AssigneeHSC Research and Development Limited Partnership
InventorsChaim M. Roifman, Peter Demin, Andrew Freywald, Thomas Grunberger, Olga Rounova, Nigel Sharfe
Life of this patent
Estimating the term…
Abstract
Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed.
Claims30
A compound of Formula I, or a salt thereof:
- wherein
- R1 and R2 are both OH or R1 and R2 are both OCH3;
- R3 is selected from C1-6alkylCO2, C1-6alkyl(C═O)NH, or C1-6alkyl(C═O)N(C1-6alkyl);
- R4 is selected from C(X)R5, SO3Ar, NH2, NH—C1-6alkyl, N(C1-6alkyl)(C1-6alkyl), P(O)(OH)2, P(O)(OC1-6alkyl)2, and C(NH2)═C(CN)2;
- X is selected from O, S, NH and N—C1-6alkyl;
- R5 is selected from NH2, OH, NH(CH2)pAr, NH(CH2)pOH, (CH2)pOC1-6alkyl, C1-6alkyl, C1-6alkoxy, NHNH2, NHC(O)NH2, NHC(O)C1-6alkoxy, N-morpholino and N-pyrrolidino;
- and
- Ar is an aromatic or heteroaromatic group, unsubstituted or substituted with 1-4 substituents, independently selected from OH, C1-6alkyl, C1-6alkoxy, NH2, NH—C1-6alkyl, N(C1-6alkyl)(C1-6alkyl), SH, S—C1-6alkyl, NO2, CF3, OCF3 and halo;
- and
- p is 1-4.
7 more elements
A compound selected from:
A compound of Formula I, or a salt thereof:
- wherein
- R1 is OCH3 and R2 is OH;
- R3 is selected from C1-6alkylCO2, C1-6alkyl(C═O)NH, or C1-6alkyl(C═O)N(C1-6alkyl);
- R4 is selected from C(X)R5, SO3Ar, NH2, NH—C1-6alkyl, N(C1-6alkyl)(C1-6alkyl), P(O)(OH)2, P(O)(OC1 6alkyl)2, and C(NH2)═C(CN)2;
- X is selected from O, S, NH and N—C1-6alkyl;
- R5 is selected from NH2, OH, NH(CH2)pAr, NH(CH2)pOH, (CH2)pOC1-6alkyl, C1-6alkyl, C1-6alkoxy, NHNH2, NHC(O)NH2, NHC(O)C1-6alkoxy, N-morpholino and N-pyrrolidino;
- and
- Ar is an aromatic or heteroaromatic group, unsubstituted or substituted with 1-4 substituents, independently selected from OH, C1-6alkyl, C1-6alkoxy, NH2, NH—C1-6alkyl, N(C1-6alkyl)(C1-6alkyl), SH, S—C1-6alkyl, NO2, CF3, OCF3 and halo;
- and
- p is 1-4.
7 more elements
Dependencies are inferred from the claim text.