Modulators of ATP-binding cassette transporters

A compound of formula II:

• or a pharmaceutically acceptable salt thereof, wherein:
• A is C(O) or SO2;
• RC and RD taken together form a 3-6 membered cycloalkyl ring;
• n is 2 or 3;
• Z is
• wherein,
• W is pyridyl, pyrazolyl, oxazazolyl, furanyl, thienyl, isoxazolyl, pyrrolyl, benzofuranyl, benzothienyl, indolyl, indazolyl, quinolinyl, isoquinolinyl or cinnolinyl and m is 0 to 5;
• RB is (C1-C4)alkoxy;
• RZ is independently selected from R1, R2, R4, or R5, wherein:
• R1 is R6, ((C1-C4)aliphatic)-Y, or Y;
• and
• Y is halo, CN, NO2, CF3, OCF3, OH, SR6, S(O)R6, SO2R6, NH2, NHR6, N(R6)2, COOH, COOR6 or OR6;
• R2 is an aliphatic, wherein each R2 comprises up to 2 substituents independently selected from R4, or R5;
• R4 is OR5, OR6, OC(O)R6, OC(O)R5, OC(O)OR6, OC(O)OR5, OC(O)N(R6)2, OC(O)N(R5)2, OC(O)N(R6R5), SR6, SR5, S(O)R6, S(O)R5, SO2R6, SO2R5, SO2N(R6)2, SO2N(R5)2, SO2NR5R6, SO3R6, SO3R5, C(O)R5, C(O)OR5, C(O)R6, C(O)OR6, C(O)N(R6)2, C(O)N(R5)2, C(O)N(R5R6), C(O)N(OR6)R6, C(O)N(OR5)R6, C(O)N(OR6)R5, C(O)N(OR5)R5, C(NOR6)R6, C(NOR6)R5, C(NOR5)R6, C(NOR5)R5, N(R6)2, N(R5)2, N(R5R6), NR5C(O)R5, NR6C(O)R6, NR5C(O)R6, NR6C(O)R5, NR6C(O)OR6, NR5C(O)OR6, NR6C(O)OR5, NR5C(O)OR5, NR6C(O)N(R6)2, NR6C(O)NR5R6, NR6C(O)N(R5)2, NR5 C(O)N(R6)2, NR5 C(O)NR5R6, NR5C(O)N(R5)2, NR6SO2R6, NR6SO2R5, NR5SO2R5, NR5SO2R6, NR6SO2N(R6)2, NR5 SO2N(R6)2, NR6SO2NR5R6, NR6SO2N(R5)2, NR5SO2NR5R6, NR5SO2N(R5)2, N(OR6)R6, N(OR6)R5, N(OR5)R5, or N(OR5)R6;
• R5 is a cycloaliphatic, aryl, heterocyclic, or heteroaryl ring, wherein each R5 is optionally substituted with up to 3 R1 substituents;
• and
• R6 is H or aliphatic, provided that when A is C(O), then the following compounds are excluded:
• ring W together with RZ
• RC & RD together
• and m
• ring B with RB & n
• cyclopentyl
• benzofuran-2-yl
• 3,4-dimethoxyphenyl
• cyclohexyl
• benzofuran-2-yl
• 3,4-dimethoxyphenyl
• cyclopentyl
• diphenylmethyl
• 3,4-dimethoxyphenyl
• cyclopentyl
• 5-bromo-furan-2-yl
• 3,4-dimethoxyphenyl.