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US 7,598,400 B2Granted
AMPO spin traps
AssigneeThe Ohio State University Research Foundation
InventorsFrederick Villamena, Christopher M. Hadad, Jay L. Zweier
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Abstract
Provided are spin traps for the study of radical formation in vivo or in vitro. 5-carbamoyl-5-methyl-1-pyrroline N-oxide (AMPO) and 2-amino-5-carbamoyl-5-methyl-1-pyrroline N-oxide (NH2-AMPO), have the following structures, respectively: as well as salts thereof.
Claims8
A compound of formula I:
- wherein R1 is selected from the group consisting of halo, alkyl, substituted alkyl, branched alkyl, and cyclic alkyl, and R2 is NH2;
- or a salt thereof.
A spin trap of formula I:
- wherein R1 is selected from the group consisting of halo, alkyl, substituted alkyl, branched alkyl, and cyclic alkyl, and R2 is NH2;
- or a salt thereof.
Dependencies are inferred from the claim text.