Acyl indoles, compositions containing such compounds and methods of use

A compound represented by formula I:

• or a pharmaceutically acceptable salt thereof, wherein:
• each R1 represents H or is independently selected from the group consisting of:
• a) OH, halo, CO2Ra, C(O)NRbRc, NRbRc, CN or S(O)pRd;
• and
• b) C1-10alkyl, C2-10alkenyl, OC1-10alkyl and OC3-10alkenyl, said groups being optionally substituted with:
• (1) 1-5 halo groups up to a perhaloalkyl group;
• (2) 1 oxo group;
• (3) 1-2 OH groups;
• (4) 1 phenyl ring, which is optionally substituted as follows:
• 1-5 halo groups up to perhalo, 1-3 C1-10alkyl or alkoxy groups, each being further optionally substituted with 1-5 halo up to perhalo;
• R2 represents phenyl optionally substituted with 1-3 halo, C1-6alkyl, C1-6alkoxy, haloC1-6alkyl and haloC1-6alkoxy groups;
• R3 represents H, C1-6alkyl;
• 3 R4 groups are present, 0-3 of which are C1-8alkyl, C2-6alkenyl, C2-6alkynyl or C1-8alkoxy groups, said groups being optionally substituted with:
• (1) 1-5 halo atoms up to perhaloalkyl;
• (2) 1 oxo group;
• (3) 1-2 OH groups;
• (4) 1-2 C1-10alkoxy groups, each optionally substituted with up to five halo atoms or a perhaloalkoxy, 1 OH or CO2Ra group;
• (5) 1-2 Aryl groups, each optionally substituted as follows:
• (i) 1-5 halo atoms, (ii) 1 OH, CO2Ra, CN, S(O)pRd, NO2 or C(O)NRbRc group, (iii) 1-2 C1-10alkyl or alkoxy groups, each optionally substituted with:
• 1-5 halo atoms, up to perhaloalkyl;
• and 0-1 of which is Aryl optionally substituted as follows:
• (1) 1-3 halo atoms;
• (2) 1-2 OH, CO2Ra, CN or S(O)pRd groups;
• (3) 1-3 C1-8alkyl groups optionally substituted with 1-5 halo groups, and (4) 1-3 C1-10alkoxy groups, the alkyl portion of which is optionally substituted with 1-5 halo groups,
• and the remainder are hydrogen atoms;
• R5 represents H, halo, C1-6 alkyl, C1-6alkoxy, haloC1-6 alkyl or haloC1-6 alkoxy;
• G represents —CHRx— wherein Rx represents H or C1-8alkyl;
• Ra is H or C1-10alkyl, optionally substituted with phenyl, OH, OC1-6alkyl, CO2H, CO2C1-6alkyl and 1-3 halo groups;
• Rb is H or C1-10alkyl;
• Rc is H or is independently selected from:
• (a) C1-10alkyl, (b) Aryl or Ar—C1-6alkyl, each optionally substituted with 1-5 halos and 1-3 members selected from the group consisting of:
• CN, OH, C1-10alkyl and OC1-10 alkyl, said alkyl and alkoxy being further optionally substituted with 1-5 halo groups up to perhalo;
• Rd is C1-10alkyl, Aryl or Ar—C1-10alkyl;
• p is an integer selected from 0, 1 and 2, and
• and Z is selected from CH2CH2CO2Ra, CH2CH(OH)CO2Ra and 5-tetrazolyl.