Crystalline solids of carvedilol and processes for their preparation
AssigneeTeva Pharmaceutical Industries Ltd.
InventorsIlan Kor-Sade, Shlomit Wizel
Life of this patent
Estimating the term…
Abstract
This invention relates to a novel crystalline solid of carvedilol or a solvate thereof, to processes for its preparation, to compositions containing it and to its use in medicine. This invention further relates to a novel process for preparing a crystalline solid of carvedilol Form II.
Claims6
A process for preparing a crystalline ethyl acetate solvate of carvedilol characterized by a PXRD pattern having peaks at about 5.8, 6.5, 7.3, 10.7, 11.1, 11.5, 13.1, 13.7, 16.0, 16.8, 17.7, 18.5, 23.0, and 30.5±0.2 degrees two-theta wherein the PXRD pattern is substantially as in FIG. 1, the process comprising the steps of:
- contacting carvedilol and ethyl acetate to form a solution, and
- cooling the solution whereby a precipitate is formed.
Dependencies are inferred from the claim text.