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US 7,598,393 B2Granted
Sulfonyl benzimidazole derivatives
AssigneePfizer Inc.
InventorsKana Kon-I, Miyako Matsumizu, Akiko Shima
Life of this patent
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Abstract
This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein A, B, R1, R2 and R3 are each as described herein, and compositions containing such compounds, and the use of such compounds in the treatment of a condition mediated by CB2 receptor activity.
Claims9
A compound of the formula (I):
- or a pharmaceutically acceptable salt thereof, wherein:
- A is a bond;
- B is CH;
- R1 is a C1-C2 alkyl group substituted with one substituent selected from the group consisting of, a hydroxy group, a trifluoromethoxy group, a C1-C4 alkoxy group, an amino group, a C1-C4 alkylamino group, a di(C1-C4 alkyl)amino group, a cycloalkyl group, an alkyl-substituted cycloalkyl group, a hydroxy-substituted cycloalkyl group, a heterocyclyl group, an alkyl-substituted heterocyclyl group and a hydroxy-substituted heterocyclyl group;
- wherein said unsubstituted or substituted heterocyclyl group is selected from the group consisting of pyrrolidinyl, tetrahydropyranyl, and tetrahydrofuranyl;
- R2 is an alkyl-substituted C3-C6 cycloalkyl group, a branched C4-C8 alkyl group, an alkoxy-substituted branched C4-C8 alkyl group, or a methyl group substituted with one substituent select from the group consisting of a C3-C5 cycloalkyl group, and an alkylsubstituted C3-C5 cycloalkyl group;
- and
- R3 is a phenyl group, a C3-C5 cycloalkyl group or a C1-C4 alkyl group, said phenyl group and said alkyl group being unsubstituted or substituted with 1 to 3 substituents independently selected from the group consisting of a halogen atom, a C1-C4 alkoxy group and a di(C1-C4 alkyl)amino group.
5 more elements
Dependencies are inferred from the claim text.