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US 7,598,387 B2Granted
Synthesis of antidiabetic rosiglitazone derivatives
AssigneeCipla Limited
InventorsDharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan
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Abstract
A process of preparing rosiglitazone, or a pharmaceutically acceptable salt thereof, which process employs an intermediate metabisulphite complex of 4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzaldehyde, which metabisulphite complex is represented by following formula (III): where X represents an alkali metal. The present invention further provides rosiglitazone, or a pharmaceutically acceptable salt thereof, prepared by the above process.
Claims16
A process of preparing rosiglitazone of formula (I), or a pharmaceutically acceptable salt thereof,
- comprising reacting a thiazolidine 2,4 dione and an intermediate metabisulphite complex of 4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzaldehyde, which metabisulphite complex is represented by following formula (III):
- where X represents an alkali metal.
Dependencies are inferred from the claim text.