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US 7,598,380 B2Granted
Method of preparation of azaindole derivatives
AssigneeBristol-Myers Squibb Company
InventorsWansheng Liu, Sunil S. Patel, Nicolas Cuniere, Yvonne Lear, Prashant P. Deshpande, Jeffrey N. Simon, Chiajen Lai, Annie J. Pullockaran, Nachimuthu Soundararajan, Jeffrey T. Bien
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Abstract
A method of preparing azaindole compounds for antiviral use having the formula
Claims15
A method of preparing a compound of formula 8:
- comprising the steps of:
- (a) converting a compound of formula 1:
- to a compound of formula 2:
- (b) converting said compound of formula 2 to a compound of formula 3:
- (c) converting said compound of formula 3 to a compound of formula 4:
- (d) converting said compound of formula 4 to a compound of formula 5:
- (e) cyclizing said compound of formula 5 to a compound of formula 6:
- (f) converting said compound of formula 6 to a compound of formula 7:
- and
- (g) coupling said compound of formula 7 with a compound of formula 9:
7 more elements
A method of preparing a compound of formula 8:
- comprising the step of coupling a compound of formula 7:
- with a compound of formula 9:
- and wherein the yield of the compound of formula 8 is up to about 90% weight, based on total weight of the reaction mixture;
- and further wherein said compound of formula 7 is prepared by the steps of:
- (a) cyclizing a compound of formula 5:
- to a compound of formula 6:
- (b) converting said compound of formula 6 to said compound of formula 7.
4 more elements
Dependencies are inferred from the claim text.