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US 7,598,347 B2Granted
RGD-enriched gelatines
AssigneeFuji Film Manufacturing Europe B.V.
InventorsJan Bastiaan Bouwstra, Andries Johannes Jozef Van Es, Yuzo Toda
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AssigneeFuji Film Manufacturing Europe B.V.
InventorsJan Bastiaan Bouwstra, Andries Johannes Jozef Van Es, Yuzo Toda
Estimating the term…
The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD sequences. More precise the percentage of RGD sequences related to the total number of amino acids is at least 0.4 and if the RGD-enriched gelatine comprises 350 amino acids or more, each stretch of 350 amino acids contains at least one RGD motif. Preferably the RGD-enriched gelatines are prepared by recombinant technology, and have a sequence that is derived from a human gelatine or collagen amino acid sequence. The invention also relates to RGD-enriched gelatines that are used for attachment to integrins. In particular The RGD-enriched gelatines of the invention are suitable for coating a cell culture support for growing anchor-dependant cell types. Further, the RGD-enriched gelatines of the invention may find use in medical applications, in particular as a coating on implant or transplant material or as a component of drug delivery systems.
An RGD-enriched gelatine comprising at least 4 RGD motifs, wherein the percentage of RGD motifs related to the total number of amino acids is at least 1.5 and if the RGD-enriched gelatine comprises 350 amino acids or more, each stretch of 350 amino acids contains at least one RGD motif.
Dependencies are inferred from the claim text.