Immunostimulatory compositions and methods
AssigneeUniversity of Louisville Research Foundation, Inc.
InventorsHaval Shirwan, Kutlu G. Elpek, Esma S. Yolcu
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Abstract
The invention provides conjugates comprising an immune co-stimulatory polypeptide and an antigen or infectious agent. The conjugates are useful for generating or enhancing an immune response against the antigen or infectious agent. The invention also provides immune cells modified with a conjugate that are useful for generating or enhancing an immune response to an antigen or infectious agent. The invention also provides immunostimulatory moieties comprising an immune co-stimulatory polypeptide that are useful for stimulating an immune response. The invention also provides immunotherapy methods and methods of treating or preventing infections.
Claims20
A combination comprising:
- (a) a conjugate comprising a 4-1BBL immune co-stimulatory polypeptide and avidin or streptavidin;
- and
- (b) a tumor associated antigen.
A method of generating or enhancing an immune response against a tumor which expresses a tumor-associated antigen, comprising administering to a patient with said tumor:
- (a) a conjugate comprising a 4-1BBL immune co-stimulatory polypeptide and streptavidin or avidin and a tumor-associated antigen;
- or
- (b) immune cells which have been treated in vitro with said conjugate and antigen.
A conjugate comprising a 4-1BBL immune co-stimulatory polypeptide and avidin or streptavidin, wherein said conjugate comprises the amino acid sequence of SEQ ID NO:
- 8.
A method of inducing an immunostimulatory response in an animal comprising administering to the animal a conjugate comprising a 4-1BBL immune co-stimulatory polypeptide and avidin or streptavidin, wherein said conjugate comprises the amino acid sequence of SEQ ID NO:
- 8.
A combination comprising:
- (a) a conjugate comprising a 4-1BBL immune co-stimulatory polypeptide and avidin or streptavidin;
- and
- (b) an antigen, wherein said antigen is not bound to said 4-1BBL conjugate.
Dependencies are inferred from the claim text.