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US 7,598,344 B2Granted
Composition, method and use of bi-functional biomaterials
AssigneeBoard of Regents, The University of Texas System
InventorsAngela M. Belcher, Christine J. Schmidt, Kiley P. H. Miller, Archit Sanghvi
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Abstract
The present invention includes a bifunctional specificity structure that includes a peptide linker having a first and a second binding domain, wherein the first binding domain is selective for a first biomaterial and the second binding domain is selective for a second biomaterial. The present invention also includes a method of making and identifying the bifunctional structure of the present invention and methods of using the same.
Claims4
An engineered bifunctional peptide comprising:
- a first peptide binding domain with length of about 7 amino acids to about 30 amino acids which binds selectively to a biomaterial wherein the first peptide binding domain is defined as a peptide amino acid sequence selected from the group consisting of the amino acid sequence of SEQ. ID. NOS.:
- 1-22;
- a second peptide binding domain with length of about 7 amino acids to about 30 amino acids which binds selectively to an electrically conductive polymer comprising polypyrrole;
- and
- a linker joining together the first and second peptide binding domains;
- wherein selective binding means that the first and second peptide binding domains include a sequence from a peptide that is not removed during washing with Tris-buffered saline containing 0.1% (vol/vol) Tween-20 (0.1% TBS-T) while bound to the biomaterial or electrically conductive polymer.
3 more elements
Dependencies are inferred from the claim text.