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US 7,598,342 B2Granted
Alpha-fetoprotein peptides and uses thereof
AssigneeAlbany Medical College
InventorsThomas T. Andersen, James A. Bennett, Herbert Jacobson, George C. Shields, Karl N. Kirschner
Life of this patent
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Abstract
The invention relates to compounds that include peptide and peptidomimetics that inhibit estrogen receptor dependent cell proliferation. The compounds of the invention are useful for treating cell proliferative disorders or physiological conditions characterized by undesirable or unwanted estrogen induced cell proliferation, including breast cancer.
Claims9
A synthetic peptide 4-7 amino acids in length, wherein said peptide comprises the amino acid sequence
- a) AA1-AA2-AA3-N
- wherein AA1 is threonine, serine, valine or alanine;
- AA2 is hydroxyproline or serine;
- AA3 is valine, isoleucine, leucine or threonine;
- b) AA′1-AA′2-AA′3-N-AA′4
- wherein AA′1 is threonine, serine, valine or alanine;
- AA′2 is hydroxyproline or serine;
- AA′3 is valine, isoleucine, leucine or threonine;
- and
- AA′4 is hydroxyproline;
- or
- c) AA1-AA2-N-AA3
- wherein AA″1 is hydroxyproline or serine;
- AA″3 is valine, isoleucine, leucine or threonine;
- and
- AA″3 is hydroxyproline;
- and wherein said peptide has anti-estrotrophic activity.
14 more elements
Dependencies are inferred from the claim text.