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US 7,598,316 B2Granted
Preparation of polymer particles
AssigneeQiagen GmbH
InventorsVidar Skagestad, Lars Kilaas
Life of this patent
Estimating the term…
Abstract
A process for the preparation of polymer magnetic particles, which comprises: providing a water phase containing magnetic components homogeneously dispersed therein, wherein the water phase is contacted with or further contains a polymerisable metal-containing or organic monomer which is soluble in the water phase, and polymerizing the monomer in the presence of the magnetic components so as to form polymer magnetic particles in which the magnetic components are substantially uniformly distributed; wherein at least a part of the polymerizing step is carried out in a water-in-oil emulsion in which the water phase containing the magnetic components homogenously dispersed therein is present as a discontinuous phase in a continuous oil phase.
Claims20
A process for the preparation of polymer magnetic particles, which comprises:
- (a) providing a water phase containing magnetic components homogeneously dispersed therein;
- (b) wherein the water phase is contacted with or further contains a polymerisable monomer comprising a metal oxide or hydroxide, or a metal alkoxide precursor compound which is converted to said monomer by hydrolysis, which is soluble in the water phase;
- and
- wherein if the metal in the metal alkoxide is silicon the metal alkoxide is tetraalkoxysilane;
- (c) polymerising the monomer in the presence of the magnetic components so as to form polymer magnetic particles in which the magnetic components are substantially uniformly distributed;
- wherein at least a part of the polymerising step (c) is carried out in a water-in-oil emulsion in which the water phase containing the magnetic components homogeneously dispersed therein is present as a discontinuous phase in a continuous oil phase, and
- wherein said process results in the magnetic particles being substantially uniformly distributed throughout the entire polymer matrix of said polymer particle.
4 more elements
A process for the preparation of polymer magnetic particles, which comprises:
- (a) providing a water phase containing magnetic components homogeneously dispersed therein, wherein the water phase is provided in a water-in-oil emulsion in which said water phase is present as a discontinuous phase in a continuous oil phase;
- (b) contacting the emulsion with a polymerisable monomer comprising a metal oxide or hydroxide, or a metal alkoxide precursor compound which is converted to said monomer by hydrolysis, which is soluble in the water phase;
- and wherein if the metal in the metal alkoxide is silicon the metal alkoxide is tetraalkoxysilane and
- (c) polymerising the monomer in the presence of the magnetic components so as to form polymer magnetic particles in which the magnetic components are substantially uniformly distributed;
- wherein at least a part of the polymerising step (c) is carried out in the water-in-oil emulsion, and
- wherein said process results in the magnetic particles being substantially uniformly distributed throughout the entire polymer matrix of said polymer particle.
3 more elements
A process for the preparation of polymer magnetic particles, which comprises:
- (a) providing a water phase containing magnetic components homogeneously dispersed therein;
- (b) wherein the water phase is contacted with or further contains a polymerisable monomer comprising a metal oxide or hydroxide, or a metal alkoxide precursor compound which is converted to said monomer by hydrolysis, which is soluble in the water phase;
- and
- wherein if the metal in the metal alkoxide is silicon the metal alkoxide is tetraalkoxysilane;
- (c) polymerising the monomer in the presence of the magnetic components so as to form polymer magnetic particles in which the magnetic components are substantially uniformly distributed;
- wherein at least a part of the polymerising step (c) is carried out in a water-in-oil emulsion in which the water phase containing the magnetic components homogeneously dispersed therein is present as a discontinuous phase in a continuous oil phase, and wherein the magnetic components comprise a ferro fluid, and
- wherein said process results in the magnetic particles being substantially uniformly distributed throughout the entire polymer matrix of said polymer particle.
4 more elements
A process for the preparation of polymer magnetic particles, which comprises:
- (a) providing a water phase containing magnetic components homogeneously dispersed therein;
- (b) wherein the water phase is contacted with or further contains a polymerisable monomer comprising a metal oxide or hydroxide which is soluble in the water phase;
- and
- (c) polymerising the monomer in the presence of the magnetic components so as to form polymer magnetic particles in which the magnetic components are substantially uniformly distributed;
- and
- wherein at least a part of the polymerising step (c) is carried out in a water-in-oil emulsion in which the water phase containing the magnetic components homogeneously dispersed therein is present as a discontinuous phase in a continuous oil phase;
- and
- wherein the largest dimension of the magnetic components is in the range 1 to 15 nm and the water phase of the emulsion comprises water droplets having a size in the range of 0.1 to 100 μm;
- and
- wherein said process results in the magnetic particles being substantially uniformly distributed throughout the entire polymer matrix of said polymer particle.
7 more elements
A process for the preparation of polymer magnetic particles, which comprises:
- (a) providing a water phase containing magnetic components homogeneously dispersed therein, wherein the water phase is provided in a water-in-oil emulsion in which said water phase is present as a discontinuous phase in a continuous oil phase;
- (b) contacting the emulsion with a polymerisable monomer comprising a metal oxide or hydroxide, which is soluble in the water phase;
- and
- (c) polymerising the monomer in the presence of the magnetic components so as to form polymer magnetic particles in which the magnetic components are substantially uniformly distributed;
- and
- wherein at least a part of the polymerising step (c) is carried out in the water-in-oil emulsion;
- and
- wherein the largest dimension of the magnetic components is in the range 1 to 15 nm and the water phase of the emulsion comprises water droplets having a size in the range of 0.1 to 100 μm;
- and
- wherein said process results in the magnetic particles being substantially uniformly distributed throughout the entire polymer matrix of said polymer particle.
7 more elements
A process for the preparation of polymer magnetic particles, which comprises:
- (a) providing a water phase containing magnetic components homogeneously dispersed therein;
- (b) wherein the water phase is contacted with or further contains a polymerisable monomer comprising a metal oxide or hydroxide which is soluble in the water phase;
- and
- (c) polymerising the monomer in the presence of the magnetic components so as to form polymer magnetic particles in which the magnetic components are substantially uniformly distributed;
- and
- wherein at least a part of the polymerising step (c) is carried out in a water-in-oil emulsion in which the water phase containing the magnetic components homogeneously dispersed therein is present as a discontinuous phase in a continuous oil phase, and wherein the magnetic components comprise a ferro fluid;
- and
- wherein the largest dimension of the magnetic components is in the range 1 to 15 nm and the water phase of the emulsion comprises water droplets having a size in the range of 0.1 to 100 μm;
- and
- wherein said process results in the magnetic particles being substantially uniformly distributed throughout the entire polymer matrix of said polymer particle.
7 more elements
Dependencies are inferred from the claim text.