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US 7,598,293 B2Granted
Compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them
AssigneeDr. Reddy's Laboratories, Inc.
InventorsBhuniya Debnath, Saibal Kumar Das, Gurram Ranga Madhaven, Javed Iqbal, Ranjan Chakrabarti, Reeba Kannimel Vikramadithyan
Life of this patent
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Abstract
The present invention relates to novel antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds of formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them.
Claims28
A compound of the formula (I)
- wherein R1 represents hydrogen, hydroxy, halogen, linear or branched (C1-C12) alkyl, linear or branched (C1-C12) alkoxy, or arylalkyl;
- R2 represents hydrogen, halogen, linear or branched (C1-C12) alkyl, linear or branched (C1-C12) alkoxy, (C1-C12) alkanoyl, aryl, arylalkanoyl, or arylalkyl;
- R3 represents hydrogen, linear or branched, (C1-C12)alkyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, aryl, (C1-C12)alkanoyl, aroyl, arylalkyl, arylalkanoyl, alkoxyalkyl, alkoxycarbonyl, aryloxycarbonyl, alkylaminocarbonyl, or arylaminocarbonyl;
- R4 represents hydrogen or linear or branched (C1-C12) alkyl;
- Y represents oxygen;
- R5 represents hydrogen or alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, aryl or arylalkyl;
- Ar represents divalent phenylene or diva lent naphthylene;
- X represents a bond;
- R6 represents hydrogen or group of the structure —OSO2R8 or —NR8SO2R9, R13 represents hydrogen or group of the structure —OSO2R8 or —NR8SO2R9, wherein R8 and R9, which are the same or different, independently represent hydrogen, alkyl, aryl, arylalkyl, alkoxycarbonyl or arylalkoxycarbonyl, with the proviso that R6 is hydrogen only when R13 is not hydrogen and is in the third position of the phenyl ring;
- and
- n is 1 to 6, and m is 0 to 6;
- and
- pharmaceutically acceptable salts of the compound of the formula (I).
10 more elements
Dependencies are inferred from the claim text.