Pyrazole derivatives, compositions containing such compounds and methods of use

A compound represented by formula I:

• or a pharmaceutically acceptable salt or solvate thereof, wherein:
• each R1 is H or is selected from the group consisting of:
• (a) halo, OH, CO2R4, CN, SOpR5 or NO2,
• (b) C1-6alkyl or OC1-6alkyl optionally substituted with:
• (1) 1-5 halo groups up to a perhaloalkyl group;
• (2) CO2R4;
• (3) phenyl optionally substituted as follows:
• (i) 1-5 halo groups, (ii) 1 CO2R4, CN, S(O)pR5, NO2 or C(O)NR6R7 group, (iii) 1-2 C1-10alkyl or alkoxy groups, each optionally substituted with:
• 1-5 halo, up to perhaloalkyl, and 1-2 OH or CO2R4 groups;
• each R2 is selected from R1 as defined above, or 2 R2 groups can be taken together to represent a fused 5-6 membered cyclic structure containing 1-2 oxygen atoms, and 1-2 carbon atoms each of which is optionally substituted with 1-2 F atoms;
• R3 is H or C1-3alkyl;
• R4 is H, C1-6alkyl, and
• R5 represents a member selected from the group consisting of:
• C1-10alkyl, Aryl or Ar—C1-10alkyl;
• R6 and R7 each independently represent H or C1-3alkyl, and p is 0, 1 or 2 group.