Indazole compounds as B3 adrenoceptor agonist

A compound of the formula (I-Indazole):

• or a salt thereof,
• wherein
• R1 represents a hydrogen atom, a hydroxyl group or a halogen atom;
• R2 represents NHSO2R3 or SO2NR4R4′;
• R3 represents a (C1-C6)alkyl group, a benzyl group, a phenyl group or NR4R4′;
• R4 and R4′ may be the same or different and each independently represents a hydrogen atom or a (C1-C6)alkyl group;
• R5 represents a hydrogen atom or a (C1-C6)alkyl group;
• R7 represents a hydrogen atom, a (C1-C6)alkyl group, a (C1-C6)alkyl group optionally substituted with one or more halogen atoms, an optionally substituted —(CH2)n-phenyl group, —CH═CH—CO2R5 or —(CH2)n—R8;
• R8 represents OR5, CN, NR41R41′, CO2R5, SO3R5, SO2(C1-C6)alkyl, SO2NR41R41′, C(═O)R5, C(═O)NR41R41′ or NR51COR5, wherein R5 is as defined above;
• R51 represents a hydrogen atom or a (C1-C6)alkyl group;
• R41 and R41′ may be the same or different and each independently represents a hydrogen atom, a (C1-C6)alkyl group or a (C3-C6)cycloalkyl group, or R41 and R41′ taken together represent a (C2-C6)alkylene group;
• or R8 is a heterocycle selected from pyridyl, pyrimidinyl, pyrazinyl, thiazolyl, oxazolyl, imidazolyl, triazolyl, 1,2,4-oxadiazolyl, isoxazolyl, tetrazolyl, pyrazolyl, hexamethyleneiminyl, piperidinyl and pyrrolidinyl, wherein one of the ring nitrogen atoms of imidazolyl, triazolyl and tetrazolyl may be optionally substituted with a (C1-C6)alkyl group which is optionally substituted with one or more halogen atoms;
• wherein with respect to one or more of the ring carbon atoms of the each heterocycle, each of them may be optionally substituted with one or more substituents which are independently selected from hydrogen, a (C1-C6)alkyl group optionally substituted with one or more halogen atoms, a halogen atom, nitro, cyano and —(CH2)n—R9;
• and wherein the ring nitrogen atom of hexamethyleneiminyl, piperidinyl and pyrrolidinyl may be substituted with a (C1-C6)alkyl group, a (C3-C6)cycloalkyl group, COR5, COOR5, CONR4R4′ or SO2R5;
• R9 represents NR4R4′, CO2R5, C (═O)—NR4R4′, OR5, SO3R5, SO2(C1-C6)alkyl or SO2NR4R4′, wherein R5, R4 and R4′ are as defined above;
• Y represents an oxygen atom, NH, a sulfur atom or a methylene group;
• R10 represents a hydrogen atom, an optionally substituted —(CH2)n-phenyl group, a —(C1-C10)alkyl group or —(CH2)n—R8, wherein R8 is as defined above;
• n is an integer of 0 to 6;
• *1 represents an asymmetric carbon atom;
• and
• *2 represents an asymmetric carbon atom when R5 is other than a hydrogen atom.