Nicotine in therapeutic angiogenesis and vasculogenesis
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsJohn Cooke, James Jang, Phillip Tsao, Christopher Heeschen
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Abstract
Methods are provided for induction of angiogenesis by administration of nicotine or other nicotine receptor agonist. Induction of angiogenesis by the methods of the invention can be used in therapeutic angiogenesis in, for example, treatment of ischemic syndromes such as coronary or peripheral arterial disease.
Claims17
A method of stimulating therapeutic angiogenesis in a mammal having a condition that is treatable by stimulating angiogenesis, the method comprising administering to the mammal a nicotine receptor agonist, or a pharmaceutically acceptable salt thereof, in an amount effective to stimulate angiogenesis, wherein said administration results in stimulation of therapeutic angiogenesis in the mammal, and wherein said administering is by topical administration.
A method of stimulating therapeutic angiogenesis in a mammal having a condition that is treatable by stimulating angiogenesis, the method comprising administering to the mammal a nicotine receptor agonist, or a pharmaceutically acceptable salt thereof, in an amount of about 0.001 mg to 1 mg per dose, wherein said administration results in stimulation of therapeutic angiogenesis in the mammal.
Dependencies are inferred from the claim text.