Reverse-turn mimetics and methods relating thereto

A method for treating a cell adhesion-mediated disease comprising administering to a warm-blooded animal in need thereof a composition comprising a therapeutically effective amount of a compound having the structure:

• wherein
• Y is selected from —CH(R5)—A—N(R1)—, —A—N(R1)—CH(R′)—, —A—N(R1)—C(═O)—, —A—C(═O)—N(R1)—, —A—CH(R1)—O— and —A—CH(R1)—N(R′)—;
• A is —(CHR′)n—, where n=0, 1 or 2;
• B is —(CHR″)m—, where m=1, 2 or 3;
• R′, R″, R2, R3 and R5 are the same or different and independently selected from an amino acid side chain moiety or an amino acid side chain derivative;
• and
• R1 and R4 are the same or different and independently selected from an amino acid, and amino acid side chain moiety, an amino acid side chain derivative, a peptide, a peptide derivative, or a protein;
• and
• wherein any two adjacent CH groups or adjacent NH and CH groups on the fused bicyclic ring may optionally form a double bond;
• in combination with a pharmaceutically acceptable carrier or diluent.