Cyclic amine BACE-1 inhibitors having a heterocyclic substituent

A compound having the structural formula

• or a pharmaceutically acceptable salt thereof, wherein
• R1 is
• X is —O—, —C(R14)2— or —N(R)—;
• Z is —C(R14)2— or —N(R)—;
• t is 0, 1, 2 or 3;
• each R is independently selected from the group consisting of H, alkyl, alkoxy, alkoxyalkyl, phenylalkyl, alkenyl, pyridylmethyl, furanylmethyl, thienylmethyl, thiazolylmethyl, cycloalkyl, and cycloalkylalkyl, wherein said alkyl, said alkoxy, said alkoxyalkyl, said phenylalkyl, said alkenyl, said pyridylmethyl, said furanylmethyl, said thienylmethyl, said thiazolylmethyl, said cycloalkyl, and said cycloalkylalkyl are unsubstituted or substituted by from 1 to 5 independently selected R32 groups;
• R2 is H, alkyl, phenyl, or phenylalkyl, wherein said phenyl and said phenylalkyl are unsubstituted or substituted by from 1 to 5 independently selected R32 groups;
• R3 is H or alkyl;
• R4 is H or alkyl;
• R5 is H or alkyl;
• each R14 is independently selected from the group consisting of H, alkyl, alkenyl, halo, —CN, haloalkyl, phenyl, phenylalkyl, cycloalkyl,
• R41 is alkyl, cycloalkyl, —SO2(alkyl), —C(O)-alkyl, —C(O)-cycloalkyl or -alkyl-NH—C(O)CH3;
• R6 and R7 are independently selected from the group consisting of H and alkyl,
• or R6 and R7, together with the ring carbon to which they are attached, form —C(O)—;
• R8 and R9 are independently selected from the group consisting of H and alkyl,
• or R8 and R9, together with the ring carbon to which they are attached, form —C(O)—;
• R12 and R13 are independently selected from the group consisting of H and alkyl, wherein said alkyl is unsubstituted or substituted by from 1 to 5 independently selected R32 groups,
• or R12 and R13, together with the ring carbon to which they are attached, form —C(O)—;
• R18 is H, alkyl, phenyl, phenylalkyl, pyridyl, oxazolyl, pyrazinyl, thienyl, imidazolyl, pyridylalkyl, oxazolylalkyl, pyrazinylalkyl, thienylalkyl, or imidazolylalkyl, wherein said alkyl, said phenyl, said phenylalkyl, said pyridyl, said oxazolyl, said pyrazinyl, said thienyl, said imidazolyl, said pyridylalkyl, said oxazolylalkyl, said pyrazinylalkyl, said thienylalkyl, and said imidazolylalkyl, are each unsubstituted or substituted by from 1 to 4 independently selected R32 groups;
• R19 is H, alkyl, phenyl, phenylalkyl, pyridyl, oxazolyl, pyrazinyl, thienyl, imidazolyl, pyridylalkyl, oxazolylalkyl, pyrazinylalkyl, thienylalkyl, or imidazolylalkyl, —SOR18, —SO2R18 or —CN, wherein said alkyl, said phenyl, said phenylalkyl, said pyridyl, said oxazolyl, said pyrazinyl, said thienyl, said imidazolyl, said pyridylalkyl, said oxazolylalkyl, said pyrazinylalkyl, said thienylalkyl, and said imidazolylalkyl, are each unsubstituted or substituted by from 1 to 4 independently seiected R32 groups;
• and
• each R32 group is independently selected from the group consisting of halo, alkyl, alkoxy, —OH, phenyl, phenoxy, phenylalkyl, —NO2, —CN, haloalkyl, and haloalkoxy,
• or two R32 groups on the same ring carbon atom are taken together to form ═O.