[1,2,4]triazolo[1,5,a]pyrimidin-2-ylurea derivative and use thereof

A compound of formula (1), or a pharmacologically acceptable salt thereof:

• wherein Ar represents a phenyl group, which may have 1 to 4 identical or different substituents selected from the group consisting of a fluoro group, chloro group, hydroxyl group, methyl group, methoxy group, ethoxy group, isopropoxy group, isobutoxy group, benzyloxy group, methoxymethoxy group, 2-methoxyethoxy group, 2-methoxyethoxymethoxy group, 2-(2-methoxyethoxy)ethoxy group, 2-[2-(2-methoxyethoxy)ethoxy]ethoxy group, tetrahydrofuran-2-ylmethoxy group, tetrahydropyran-4-ylmethoxy group, 2-[1,3]dioxan-2-ylethoxy group, 2-dimethylaminoethoxy group, 3-dimethylaminopropoxy group, 2-diethylaminoethoxy group, 2-morpholin-4-yl-2-oxoethoxy group, 2-piperidin-1-ylethoxy group, 3-piperidin-1-ylpropoxy group, 2-morpholin-4-ylethoxy group, 3-morpholin-4-ylpropoxy group, pyridin-2-ylmethoxy group, pyridin-3-ylmethoxy group, pyridin-4-ylmethoxy group, amino group, dimethylamino group, diethylamino group, and methylenedioxy group;
• a 2,3-dihydrobenzofuran-5-yl group, or a thiophen-2-yl group;
• X represents O;
• and R represents a hydrogen atom or a group represented by any one of the following formulas (2) to (6):
• wherein R4 represents a hydrogen atom, a methyl group, an ethyl group, or an isopropyl group;
• R5 represents a hydrogen atom or a methyl group;
• and
• R6 represents a hydrogen atom, a methoxybutenyl group, or a (C1-C6) alkyl group, which may have 1 to 2 identical or different substituents selected from the group consisting of a cyclopentyl group, a cyclohexyl group, a morpholin-4-yl group, a hydroxyl group, a methoxy group, an ethoxy group, an n-propoxy group, an isopropoxy group, an isobutoxy group, a tert-butoxy group, an acetyl group, a propionyl group, a phenyl group, a halogenophenyl group, a pyridyl group, an imidazolyl group, a (C1-C6) alkyloxycarbonyl group, a phenylaminocarbonyl group, a tetrahydrofurfurylaminocarbonyl group, a morpholin-4-ylcarbonyl group, a 2-methyl[1,3]dioxolan-2-yl group, and a di(C1-C6)alkylamino group, which may be substituted with 1 to 2 identical or different substituents selected from a (C1-C6)alkyl group, a (C1-C6)acyl group, a (C1-C6)acyloxy(C1-C6)acyl group, and a (C1-C6)alkoxycarbonyl group,
• wherein R7 represents a hydrogen atom, a methyl group, or an ethyl group;
• R8 represents a tetrahydrofuran-2-yl group or a tetrahydropyran-4-yl group;
• and
• the sum of p and q is an integer of 4 or less,
• wherein R9 represents a hydrogen atom, a methyl group, or an ethyl group;
• and
• R10 represents a phenyl group having 1 to 4 substituents selected from the group consisting of a hydroxy group, a (C1-C6)alkoxy group, a halogeno group, a (C1-C6)alkoxycarbonyl group, a nitro group, a methylenedioxy group, a benzyloxycarbonyloxy group, and a methanesulfonyloxy group;
• a naphthyl group, or a pyridyl group,
• wherein Cy represents a phenyl group, a cyclopentyl group, a cyclohexyl group, an adamantyl group, a 1,2,3,4-tetrahydronaphthalen-1-yl group, or a piperadinyl group, which may be substituted with 1 to 4 identical or different groups selected from the group consisting of a hydroxyl group, a carboxyl group, a benzyl group, a (C1-C7)-acyl group, a (C1-C6)-alkoxycarbonyl group, an N—(C1-C6)-alkylcarbamoyl group, an N,N-di(C1-C6)alkylcarbamoyl group, and
• wherein Y represents a single bond;
• R11 represents a hydrogen atom, a methyl group, an ethyl group, a n-propyl group, or an isopropyl group;
• and
• R12 represents a hydroxyl group, a (C1-C6) alkoxyl group, an amino group, a (C1-C6) alkylamino group, which may be substituted with 1 to 2 identical or different substituents selected from the group consisting of a(C1-C6)alkoxyl group, a (C1-C6)alkoxycarbonyl group, a phenyl group, a pyridyl group, an amino group represented by the formula NR13R14 (wherein each of R13 and R14 independently represents a hydrogen atom or a (C1-C6)alkyl group), a piperidin-1-yl group, a morpholin-4-yl group, and a piperazinyl group which may be substituted with a (C1-C6) alkyl group, a di(C1-C6) alkylamino group, which may be substituted with 1 to 2 identical or different substituents selected from said substituent group [C], a cyclohexylmethylamino group, a phenylamino group, a tetrahydrofurfurylamino group, a piperidin-1-yl group, a morpholin-4-yl group, or a piperazinyl group which may be substituted with a (C1-C6)alkyl group.