Diazabicyclic central nervous system active agents

A compound of formula I

• or pharmaceutically acceptable salts thereof, wherein
• A is a covalent bond;
• B is CH2;
• Y is selected from the group consisting of a covalent bond, CH2, and CH2CH2;
• Z is selected from the group consisting of a covalent bond, CH2, and CH2CH2, provided that when Y is CH2CH2, then Z is a covalent bond and further provided that when Z is CH2CH2, then Y is a covalent bond;
• R1 is selected from the group consisting of
• R3 is selected from the group consisting of hydrogen, alkyl, and halogen;
• R4 is selected from the group consisting of hydrogen, alkoxy, alkyl, amino, halogen, and nitro;
• R5 is selected from the group consisting of hydrogen, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, alkylcarbonyl, alkylcarbonyloxy, alkylthio, alkynyl, amino, aminoalkyl, aminocarbonyl, antinocarbonylalkyl, aminosulfonyl, carboxy, carboxyalkyl, cyano, cyanoalkyl, formyl, formylalkyl, haloalkoxy, halo alkyl, halogen, hydroxy, hydroxyalkyl, mercapto, mercaptoalkyl, nitro, 5-tetrazolyl, —NR6S(O)2R7, —C(NR6)NR7R8, —CH2C(NR6)NR7R8, —C(NOR6)R7, —C(NCN)R6, —C(NNR6R7)R8, —S(O)2OR6, and —S(O)2R6;
• R6, R7, and R8 are independently selected from the group consisting of hydrogen and alkyl;
• and
• R9 is selected from the group consisting of hydrogen, alkoxycarbonyl, alkyl, amino, aminoalkyl, aminocarbonylalkyl, benzyloxycarbonyl, cyanoalkyl, dihydro-3-pyridinylcarbonyl, hydroxy, hydroxyalkyl, and phenoxycarbonyl.