Therapeutic methods and agents for diseases associated with decreased expression of AOP-1 gene or AOP-1
AssigneeAsubio Pharma Co., Ltd.
InventorsFumiyuki Hattori, Keijiro Sugimura, Mayumi Furuya
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Abstract
A prophylactic or therapeutic method for a disease associated with decreased expression of AOP-1 gene or AOP-1, comprising (1) transfecting a nucleic acid encoding AOP-1 or a nucleic acid encoding a polypeptide having an addition, deletion or substitution of one or more amino acids as compared with the amino acid sequence of AOP-1 while retaining the function of AOP-1, or (2) administering a material enhancing the expression of AOP-1 gene, a material enhancing the production of AOP-1 or a material enhancing the function of AOP-1.
Claims5
A method for treating a heart disease, comprising administering by direct injection into a heart an expression vector comprising a nucleic acid sequence encoding AOP-1 operably linked to a promoter, wherein expression of said nucleic acid sequence within cells of the heart enhances the production of AOP-1, and wherein said expression of AOP-1 protects against myocardial cellular death or maintains the heart pulsating function in said heart.
Dependencies are inferred from the claim text.