Modulation of apolipoprotein C-III expression
AssigneeIsis Pharmaceuticals, Inc.
InventorsRosanne M. Crooke, Mark J. Graham, Kristina M. Lemonidis, Kenneth W. Dobie
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Abstract
Compounds, compositions and methods are provided for modulating the expression of apolipoprotein C-III. The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein C-III. Methods of using these compounds for modulation of apolipoprotein C-III expression and for diagnosis and treatment of disease associated with expression of apolipoprotein C-III are provided.
Claims28
A method of treating an animal having hyperlipidemia, said method comprising:
- administering to an animal suffering from hyperlipidemia an antisense compound comprising an antisense oligonucleotide, wherein said antisense oligonucleotide specifically hybridizes within nucleotides 3253-3558 of SEQ ID NO:4 and consists of 15 to 30 linked nucleosides, thereby reducing hyperlipidemia in said animal.
A method of delaying the onset of hyperlipidemia in an animal, said method comprising:
- administering to an animal at risk for developing hyperlipidemia an antisense compound comprising an antisense oligonucleotide, wherein said antisense oligonucleotide specifically hybridizes within nucleotides 3253-3558 of SEQ ID NO:4 and consists of 15 to 30 linked nucleosides, thereby delaying the onset of hyperlipidemia.
A method of lowering cholesterol levels in an animal comprising:
- administering to an animal in need of a reduction in cholesterol levels an antisense compound comprising an antisense oligonucleotide, wherein said antisense oligonucleotide specifically hybridizes within nucleotides 3253-3558 of SEQ ID NO:4 and consists of 15 to 30 linked nucleosides, wherein said administering results in reduced cholesterol levels in said animal.
A method of lowering triglyceride levels in an animal comprising:
- administering to an animal in need of a reduction in triglyceride levels an antisense compound comprising an antisense oligonucleotide, wherein said antisense oligonucleotide specifically hybridizes within nucleotides 3253-3558 of SEQ ID NO:4 and consists of 15 to 30 linked nucleosides, wherein said administering results in reduced triglyceride levels in said animal.
Dependencies are inferred from the claim text.