Dual chain synthetic heparin-binding growth factor analogs
AssigneeBioSurface Engineering Technologies, Inc.
InventorsPaul O. Zamora, Louis A. Pena, Xinhua Lin
Life of this patent
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Abstract
The invention provides synthetic heparin-binding growth factor analogs having two peptide chains each branched from a branch moiety, such as trifunctional amino acid residues, the branch moieties separated by a first linker of from 3 to about 20 backbone atoms, which peptide chains bind a heparin-binding growth factor receptor and are covalently bound to a non-signaling peptide that includes a heparin-binding domain, preferably by a second linker, which may be a hydrophobic second linker. The synthetic heparin-binding growth factor analogs are useful as pharmaceutical agents, soluble biologics or as surface coatings for medical devices.
Claims9
A compound of formula II:
- wherein:
- R3 and R5 are each independently NH2, an acyl group with a linear or branched C1 to C17 alkyl, aryl, heteroaryl, alkene, alkenyl or aralkyl chain including an N-terminus NH2, NH3+, or NH group or a corresponding acylated derivative, or is amino acid, a dipeptide or a tripeptide with an N-terminus NH2, NH3+, or NH group or a corresponding acylated derivative;
- R4 is —OH, NH2, NH—R7, or is an amino acid, a dipeptide or a tripeptide with a C-terminus —OH, NH2, or NH—R7;
- R7 is an aliphatic C1 to C17 chain;
- each X comprises a sequence selected from SEQ ID NO:57, SEQ ID NO:58, and SEQ ID NO:64;
- J1 and J2 are each independently a trifunctional alpha amino acid residue, wherein each X is covalently bonded through a side chain of J1 or J2;
- R6 is a linker comprising a chain from 1 to about 20 backbone carbons covalently bonded to J1 and J2;
- Y is a linker comprising a chain from 0 to about 50 backbone carbons covalently bonded to J2 and Z;
- and
- Z is SEQ ID NO:2.
Dependencies are inferred from the claim text.