Catalytic nanoparticles for nerve-agent destruction

A particle having a diameter, comprising an inorganic metal oxide and a stabilizing compound comprising a nucleophilic moiety;

• wherein said diameter is about 1 to about 1,000 nm;
• and said stabilizing compound comprising a nucleophilic moiety is a polymer or co-polymer;
• wherein said polymer or co-polymer comprises a plurality of monomers represented by formula X:
• wherein, independently for each occurrence,
• X is —C(═N—OH)—R3 or —C(═O)—N(R)—OH;
• W is absent, —O—, —N(R)—, —S—, —C(═O)O—, —C(═O)N(R)—, —C(═O)S—, —S(═O)—, —S(═O)2—, —C(R3)2—, —C(═O)—, —C(═NR3)—, —C(═S)—, —C(R3)═C(R3)—, —C≡C—, -cycloalkyl-, -heterocycloalkyl-, -cycloalkenyl-, -heterocycloalkenyl-, -aryl-, or -heteroaryl-;
• R is —C(═O)OR3, —C(═O)N(R3)2, —C(═O)SR3, —C(═O)R3, C(═NR3)R3, —C(═S)R3, —C(R3)═C(R3)2, —C≡CR3, —[C(R3)2]p—R3, hydrogen, alkyl, cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl, or heteroaryl;
• R1 is —OR, —NR2, —SR, —C(═O)OR, —OC(═O)R, —NRC(═O)R, —C(═O)NR2, —C(═O)SR, —SC(═O)R, —S(═O)R, —S(═O)2R, —C(═O)R3, —C(═NR)R3, —C(═S)R3, —C(R3)═C(R3)2, —C≡C R3, —C≡N, —[C(R3)2]p—R, hydrogen, alkyl, cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl, or heteroaryl;
• R2 is hydrogen or alkyl;
• R3 is hydrogen, halogen, alkyl, cycloalkyl, heterocycloalkyl, alkenyl, cycloalkenyl, heterocycloalkenyl, alkynyl, cyano, aryl, or heteroaryl;
• and
• n is 0-5 inclusive;
• m is 0-5 inclusive;
• and
• p is 0-10 inclusive.