Compositions and methods for the therapy and diagnosis of ovarian cancer
AssigneeCorixa Corporation
InventorsGary R Fanger, Steven P Fling
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Abstract
Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.
Claims9
A method for detecting the presence of an ovarian cancer in a patient, comprising the steps of:
- (a) obtaining a biological sample from the patient;
- (b) contacting the biological sample with an antibody or antigen binding fragment thereof, that binds to a polypeptide comprising the amino acid sequence set forth in SEQ ID NO:
- 215;
- (c) detecting in the sample an amount of said polypeptide that binds to said antibody or antigen binding fragment thereof;
- and
- (d) comparing the amount of said polypeptide to a predetermined cut-off value and therefrom determining the presence of a cancer in the patient, wherein the detection of an amount of said polypeptide that is higher than the cut-off value is considered positive for the presence of ovarian cancer.
Dependencies are inferred from the claim text.