Back to results
US 7,598,050 B2Granted
Methods of identifying compounds that modulate IL-4 receptor-mediated IgE synthesis utilizing a chloride intracellular channel 1 protein
AssigneeRigel Pharmaceuticals, Inc.
InventorsEsteban Masuda, Todd M. Kinsella, Justin E. Warner, Taisei Kinoshita, Mark K. Bennett, David C. Anderson
Life of this patent
Estimating the term…
Abstract
The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a chloride intracellular channel 1 (CLIC1) as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.
Claims14
A method for identifying a compound that modulates Chloride Intracellular Channel Protein 1 (CLIC1) activity and interleukin-4 (IL-4) induced IgE production, comprising:
- a) assaying a compound for modulation of CLIC1 activity, wherein said CLIC1 comprises an amino acid sequence that is at least 80% identical to SEQ ID NO:10 and wherein said CLIC1 activity is a chloride ion channel activity of said CLIC1;
- b) assaying said compound for modulation of IL-4 induced IgE production;
- and
- c) identifying a compound, wherein said compound modulates both CLIC1 activity and IL-4 induced IgE production.
1 more element
Dependencies are inferred from the claim text.