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US 7,598,041 B2Granted
HIV-1 VPR interactions with mitochondrial apoptosis inducing factor and methods of using the same
AssigneeThe Trustees of the University of Pennsylvania
InventorsDavid B. Weiner, Karuppiah Muthumani
Life of this patent
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Abstract
Assays to identify Vpr/AIF interaction and translocation inhibitors are disclosed.
Claims5
A method of identifying compounds that inhibit HIV Viral Protein R (Vpr) binding to Apoptosis-inducing Factor (AIF) comprising a test assay that comprises the steps of:
- i) contacting a) isolated HIV Vpr and b) isolated AIF in the presence of c) a test compound and
- ii) comparing the level of isolated HIV Vpr binding to isolated AIF to the level of isolated HIV Vpr binding to isolated AIF in the absence of said test compound.
Dependencies are inferred from the claim text.