Compositions and methods for detecting and treating prostate disorders
AssigneeThe Regents of the University of Michigan
InventorJill A. Macoska
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Abstract
The present invention relates to compositions and methods for the detecting, treating, and empirically investigating cellular proliferation disorders and cellular motility disorders. In particular, the present invention provides compositions and methods for using CXCL chemokines (e.g., CXCL1, CXCL5, CXCL6, CXCL12), CXCL receptors (e.g., CXCR1, CXCR2, CXCR4, CXCR7), and/or pathway related compounds (e.g., NF-kappaB, ERK ½, ELK-1) in the diagnosis, treatment, and empirical investigation of prostate disorders (e.g., prostate cancer, benign prostatic hypertrophy, prostatitis).
Claims6
A method for characterizing prostate tissue in a subject, comprising:
- a) providing a sample from a subject suspected of having a prostatic disease, wherein said subject has a PSA level at or less than 10 ng/ml, wherein said sample is selected from the group consisting of prostate tissue, serum, plasma, mucus, blood, and urine;
- b) detecting and comparing the amount of expression of CXCL5 and CXCL12 in said prostate tissue sample;
- and
- c) characterizing said prostate tissue sample as indicative of prostate cancer or benign prostatic hyperplasia based upon said comparing, wherein a higher amount of detected CXCL12 expression than CXCL5 expression is indicative of prostate cancer, wherein a higher amount of detected CXCL12 expression than CXCL5 expression is indicative of prostate cancer.
Dependencies are inferred from the claim text.