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US 7,597,908 B2Granted
Use of microparticles with adsorbed antigen to stimulate immune responses
AssigneeNovartis Vaccines and Diagnostics, Inc.
InventorsDerek O'Hagan, Gary Van Nest, Gary S. Ott, John Barackman, Jina Kazzaz
Life of this patent
Estimating the term…
Abstract
The use of poly(lactide) or poly(lactide-co-glycolide) microparticles with adsorbed antigen is disclosed. The microparticles are useful for enhancing CTL responses to a selected antigen.
Claims26
A method of producing a microparticle with adsorbed antigen comprising:
- (a) forming a microparticle that comprises a poly(α-hydroxy acid) by a method comprising (i) forming an emulsion comprising said poly(α-hydroxy acid), water and an organic solvent and (ii) evaporating said solvent;
- and
- (b) adsorbing an antigen derived from a viral pathogen to the surface of said microparticle.
Dependencies are inferred from the claim text.