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US 7,597,899 B2Granted
Compositions comprising a combination of a free sphingoid base and ceramide and uses thereof
AssigneeCosmoferm B.V.
InventorJohannes Wilhelmus Jacobus Lambers
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Abstract
The present invention discloses a composition for topical use comprising a free sphingoid base and a ceramide. The compositions of the invention are suitable for application to skin conditions associated with an impaired barrier function, in particular to skin conditions further associated with a deranged regulation of cell growth and differentiation, an inflammatory condition and/or an infectious state.
Claims15
A composition for topical use comprising a combination of a free sphingoid base and a ceramide, said free sphingoid base having a general structure according to Formula 1:
- wherein:
- A is C(H)OH-CH2, and
- R is a straight chain or branched alkyl group having 10 to 22 carbon atoms, and said ceramide having a general structure according to Formula 2:
- wherein:
- A and R are defined as above, and
- R′ is a straight chain or branched alkyl group having 13 to 55 carbon atoms;
- may
- optionally contain one or more double bonds;
- and may
- optionally be substituted with one or more hydroxyl groups.
7 more elements
Dependencies are inferred from the claim text.